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Prof. Tadeusz Wysocki (University of Nebraska – Lincoln, Nebraska, United States)

Tadeusz Antoni Wysocki (IEEE M'94 - SM'98), received the M.Sc.Eng. degree with the highest distinction in telecommunications from the Academy of Technology and Agriculture, Bydgoszcz, Poland, in 1981. In 1984, he received his Ph.D. degree, and in 1990, was awarded a D.Sc. degree (habilitation) in telecommunications from the Warsaw University of Technology.
In 1992, he moved to Perth, Western Australia to work at Edith Cowan University. He spent the whole 1993 at the University of Hagen, Germany, within the framework of Alexander von Humboldt Research Fellowship. In December 1998, he moved to the University of Wollongong, NSW, as an Associate Professor, within the School of Electrical, Computer and Telecommunications Engineering. Since the fall of 2007, he has been with the University of Nebraska - Lincoln as a Professor of Electrical and Computer Engineering. He also holds a title of a Full Professor at the UTP University of Science and Technology, Bydgoszcz, Poland. The main areas of his research interests include: space-time signal processing, diversity combining, and indoor propagation of microwaves, molecular communications at nano-scale and its applications in microbiology and medicine including modeling of biological processes at cellular/sub-cellular scale and inter/intra-cell communications. He is an author or co-author of over 260 research papers.

"Use of Queueing Networks to Model Sub-cellular Scale Biological Processes"

In order to study biological processes that happen at sub-cellular level, like cell metabolism, viral infections or those processes that involve human interactions with living cells, like cell transfection or targeted drug delivery, accurate, scalable and inexpensive in-silico models are necessary. The seminar will present an application of queueing networks to develop such simulation models that can significantly speedup analysis of those processes and reduce expenses associated with laboratory experiments. The simulation in-silico can also help in identifying bottlenecks in signaling pathways and facilitate studying cell responses to changes in underlying conditions (e.g. initial concentrations of proteins, changing reaction speeds, etc.). The proposed solution is to use a modeling approach based on queuing theory and stochastic modeling to build simulation models tailored to particular biological/medical application. In the presentation, the fundamental aspects of the modeling as well as some of the developed models will be presented and results of simulations compared with the available experimental data.
Prof Maria Siwek (UTP University of Science and Technology, Bydgoszcz, Poland)
Maria Siwek Phd, D.Sc., did her Phd at Wageningen University and Research Center (The Netherlands). She worked as an Experienced Researcher at University of Palermo. Currently she is an Associate Professor at Animal Biochemistry and Biotechnology Department and Head of Animal Genomics Unit. Her background is in Animal Genetics. Her current research is focused on avian immunogenetics and opportunities of its modifications. She is an author or coauthor of over 40 per review papers. Maria Siwek received Marie Curie Fellowship twice. She is a member of National Science Center Expert Panel and a member of European Commission Expert Panel. 
"Synbiotics for in ovo delivery - in vitro design, in vivo effects"
Synbiotics are synergistic combinations of prebiotics and probiotics. In chickens, synbiotics can be delivered in ovo, during embryo development, to expedite colonization of the gut by beneficial bacteria. We therefore aimed to design synbiotics in vitro and validate them in broiler chickens upon in ovo delivery. The probiotic components of the synbiotics were Lactobacillus salivarius and Lactobacillus plantarum. During the workshop synbiotic in vitro design will be presented and discussed: e.g. bacterial growth assessed in MRS medium supplemented with different prebiotics. Subsequently in vivo effects of two synbiotics S1 – Lactobacillus salivarius with galactooligosaccarides (GOS) and S2 – Lactobacillus plantarum with raffinose family oligosaccharides (RFO) delivered to Cobb broiler chicken embryos on day 12 of incubation will be described.

Dr Mazen Shahin (Delaware State University, Dover, Delaware United States)
Mazen Shahin obtained his BS in Mathematics and Physics from Alexandria University, Alexandria, Egypt, and his Ph.D. degree in Functional Analysis from Lvov State University, Lvov, USSR. He spent one year as a research fellow at Florence University, Florence, Italy by the invitation of the Italian National Research Council. He obtained a certificate from the Institute of Retraining in Computer Science (IFRICS) at Kent State University, Kent, OH, USA. Dr. Shahin’s research interests include boundary value problems, dynamical systems and mathematics education. He has extensive background and experience in designing interdisciplinary instructional materials that integrate technology, mathematics and other disciplines such as biology, ecology, and finance. He offered numerous workshops and made presentations at international conferences on use of technology in mathematics education. Shahin published two bestselling books “Explorations of Mathematical Models in Biology with MATLAB” and “Explorations of Mathematical Models in Biology with Maple” published by Wiley. He coauthored the book “A Practical Guide to Cooperative Learning in Collegiate Mathematics” published by the Mathematical Association of America (MAA). Dr. Shahin is the founder and Director of several student-centered programs for graduate, undergraduate, and high school students. He obtained numerous grants from funding agencies to run these programs. He obtained four (4) faculty excellence awards at Delaware State University over the past 16 years.
"Explorations of Mathematical Models in Biology with MATLAB"
In this talk we will present samples of mathematical models in biology which are selected from the textbook “Explorations of Mathematical Models in Biology with MATLAB” by Mazen Shahin. The main mathematical tools are difference equations and matrix algebra. Approach that facilitates ways of learning and using software such as MATLAB is an integrated part of this inquiry-based learning course where students work in small groups on carefully designed activities and utilize the numeric and graphic capabilities of the software to build, analyze, and verify models in life sciences. The students are required to conduct research projects on the investigated topics.
As an illustration of our approach, we will discuss the following two models: logistic growth and renewable natural resources management model. As potential research projects on these topics the students are required to investigate the calculations of the Maximum Sustainable Yield (MSY) of (i) Blue Shark in the North Pacific, and (ii) Bottom Fish in Hawaiian Archipelago. We will discuss the behavior of a logistic equation which exhibits the following characteristics: stable growth, cyclic growth and chaotic behavior. While conducting a research project students investigate results of application of a practical method to remove the chaotic behavior from a chaotic system. Let us consider a population in which a contagious disease is spreading. The population consists of three groups: susceptible, infected, and removed (or recovered). We will discuss the SIR and SIS models.

Prof. Jim Mazurkiewicz (Texas Agricultural and Mechanical University – College Station, Texas, United States)

For the biographical note see enclosed file.

"Water: our most precious resource"
Dr Thomas Goudoulas (Technische Universität München, Munich, Germany)
Thomas Goudoulas, Chemical Engineer, obtained his PhD in experimental rheology by the Aristotle University of Thessaloniki, in 2003. He has been assigned as adjunct Assistant Professor in Greek Universities and Technological Institutes, continuously for about a decade (2004 -2013). During that period, there was also a successful professional activity as consultant engineer on R&D issues, for five years. He has participated in a number of national and international research projects, as an expert mainly in fluid mechanics and rheology. His published work comprises rheological characterization of suspensions as well as studies of various biomaterials (e.g. synovial fluid, alginate foulants, biofilms from Multi-phase Bioreactors) and linear, high-molecular weight polymers in semi-dilute conditions. Currently, he is a senior researcher in experimental projects of complex biofluids in TUM, WZW Freising, Germany. His research interests include gelation properties of binary mixtures, rheology of soft matter and rheo-PIV. The latter one is a custom-made setup of a rheometer engaged with a laser to obtain insights into the microstructure of dense polymer solutions; for example, identifying shear banding in semi-dilute conditions. Emphasis is now given particularly to biomaterials, both on developing successful preparation methods and on new techniques for appropriate rheological characterization (in situ measurements, etc.).
"Linear and nonlinear viscoelasticity of biomaterials as a robust characterization method"
Viscoelastic parameters, like the complex viscosity, the storage and loss moduli, of biomaterials can provide valuable information on both fundamentals of biopolymer physics and applications of such materials. A wide range of deformations can be applied to diluted solutions of proteins or even to concentrated gel-like polysaccharide mixtures, especially when one considers real conditions of applications. For example, in the human body, from the small deformations in passive movements in a joint to the high strains that the human skin can experience during shaving or walking. Therefore, measuring and evaluating the linear and non-linear mechanical behavior of biomaterials is of great importance. We will try to give the principals of this rheological method, along with a few up-to-date significant results. 

Dr Stanisław Jung (UTP University of Science and Technology, Bydgoszcz, Poland)
"Treatment of osteoarthritis: current concepts and future perspectives"
With prolonged life longevity ostaeoarthritis of the joints mainly at lower extremities became a growing problem both for those affected but also for society. The OA process starts with the destruction of the cartilage and pour efforts are directed to stop or even reverse this process. Current non-operative approach include variety of methods, but results are either short term or doubtful. The non steroid anti-inflammatory medicines are acting mainly on pain component of the disease, but the side effects may be serious. The idea of beneficial role of supplementation of synovial fluid or cartilage components was implemented in medical practice some 15 years ago with glucosamine. Thereafter some more products as collagen, hyaluronic acid, chondroitin sulphate came to therapeutical agenda. Among them, only hyaluronic acid has been given intrarticularily. However the results are not solid. Present studies on this product focus on the specific characteristic of the hyaluronic acid molecule, its concentration and possible reaction with molecules of other synovial fluid components as lipids and lubricin. Computer simulation techniques proved helpful in these studies. The cell culture idea is being applied but the method is more invasive. Other promising trials already at clinical stage are using the blood derived products injected into affected joint space. The platelet enriched serum with anti-inflammatory agents contains several different growth and different cytokines factors which stimulate the healing process. The perspective of use stem cells seems also promising.

Dr Jacek Siódmiak (UTP University of Science and Technology, Bydgoszcz, Poland)
"Neurodegenerative protein aggregation in confined space"
In this presentation the results of molecular dynamics simulation on the influence of boundary conditions (B.C.) and crowding particles on protein conformation and their aggregation will be presented. There is a number of publications (based on experimental as well as theoretical results) where authors indicate that proteins in confined and crowded environments can fold incorrectly. The available space can be limited by cell boundaries and/or crowded macromolecules. Misfolded proteins have modified or even toxic functionality. Moreover, they have a high tendency to form oligomers and larger polymers. The increased levels of aggregated proteins in the cell lead to formation of amyloid-like structures which can cause degenerative disorders and cell death. Amyloid fibrils formed by misfolded proteins are responsible for neurodegenerative diseases like Alzheimer's, Parkinson's and Huntington's disease.

M.Sc. Piotr Bełdowski (UTP University of Science and Technology, Bydgoszcz, Poland)
"Hyaluronan-micelle interaction in terms of nano(bio)lubrication"
The system of articular cartilage provides very low friction and wear during a lifetime. These properties are due to phenomena occurring at many scales: from nano- to macro-. The seminar will present the interaction of two components of synovial fluid, namely hyaluronic acid and phospholipids and their influence on the mechanism of lubrication. The presented system show up similarities to capstan solution used at macroscale. The steered molecular dynamics simulation will be used to model the process in silico. The possible role of other synovial fluid components will be discussed.

M.Sc. Angela Andrzejewska (UTP University of Science and Technology, Bydgoszcz, Poland)
"3D printing: an innovative technology for bone scaffolds"
Bone is the hardest tissue of the human body. It's mechanical properties allow for transfer of large amounts of tension and pressure from the whole body. The main functions of the bone are protecting the inner organs and tissues from damage when the body receives a serious impact and providing a supporting structure to complete physical movements. Bone substitutes must perform the same functions as the native bone. Today's technology allows the creation of bone substitutes with Additive Manufacturing (AM). Novel materials like titanium, natural or synthetic polymers and biocomposites used in AM, proper strength and biocompatibility of the construction provides.
The seminar will present methods of bone scaffolds manufacturing and mechanical properties of 3D-printed parts. Moreover, influence of simulated body fluid conditions on mechanical properties will be discussed.

Zmieniony ( 06.06.2017. )

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